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Chapter 15: Substance Use Disorder Treatment Drugs

14 problems · 0 figures

Case Study 15.2.1 §15.2 source ↗

Read the following clinical scenario to answer the questions that follow. This case study will evolve throughout the chapter.

Daniel Nguyen is a 34-year-old client who presents to his health care provider’s office stating that he wishes for help with his prescription opioid use.

History
Opioid use disorder: takes prescription oxycodone when he can acquire it
Cigarette smoking: smokes 1 pack per day for 7 years
Major depressive disorder
Chronic back pain—developed after a workplace injury at his construction job 5 years ago

Current Medications
Duloxetine 40 mg orally daily
Oxycodone 20 mg orally as needed for pain

Based on the information above, what is a priority question for the nurse to ask Daniel?
  1. a.
    “Have you ever been arrested?”
  2. b.
    “When was your last opioid use?”
  3. c.
    “Where do you get your opioids from?”
  4. d.
    “Have you lost or gained weight recently?”
Table 15.3 in the book ↗
Vital Signs Physical Examination
Temperature: 98.4°F

• Head, eyes, ears, nose, throat (HEENT): Within normal limits

• Cardiovascular: No jugular vein distention; no peripheral edema noted bilaterally; S1, S2 noted, rhythm regular

• Respiratory: Clear to auscultation bilaterally

• GI: Abdomen soft, nontender, nondistended

• GU: Reports normal urine output

• Neurological: Alert and oriented to person, place, and time; no motor deficits noted

• Integumentary: No wounds noted; skin color appropriate for age

Blood pressure: 126/75 mm Hg
Heart rate: 78 beats/min
Respiratory rate: 16 breaths/min
Oxygen saturation: 99% on room air
Height: 5'8"
Weight: 175 lb

Answer

B. “When was your last opioid use?”
This is important to assess in case the client is prescribed buprenorphine or naltrexone to avoid withdrawal symptoms.

Case Study 15.2.2 §15.2 source ↗

Read the following clinical scenario to answer the questions that follow. This case study will evolve throughout the chapter.

Daniel Nguyen is a 34-year-old client who presents to his health care provider’s office stating that he wishes for help with his prescription opioid use.

History
Opioid use disorder: takes prescription oxycodone when he can acquire it
Cigarette smoking: smokes 1 pack per day for 7 years
Major depressive disorder
Chronic back pain—developed after a workplace injury at his construction job 5 years ago

Current Medications
Duloxetine 40 mg orally daily
Oxycodone 20 mg orally as needed for pain

What effects of opioid withdrawal should the nurse educate the client about that can happen if he continues taking opioids along with naltrexone?
  1. a.
    Hypotension
  2. b.
    Respiratory depression
  3. c.
    Lethargy
  4. d.
    Diarrhea
Table 15.3 in the book ↗
Vital Signs Physical Examination
Temperature: 98.4°F

• Head, eyes, ears, nose, throat (HEENT): Within normal limits

• Cardiovascular: No jugular vein distention; no peripheral edema noted bilaterally; S1, S2 noted, rhythm regular

• Respiratory: Clear to auscultation bilaterally

• GI: Abdomen soft, nontender, nondistended

• GU: Reports normal urine output

• Neurological: Alert and oriented to person, place, and time; no motor deficits noted

• Integumentary: No wounds noted; skin color appropriate for age

Blood pressure: 126/75 mm Hg
Heart rate: 78 beats/min
Respiratory rate: 16 breaths/min
Oxygen saturation: 99% on room air
Height: 5'8"
Weight: 175 lb

Answer

D. Diarrhea
Diarrhea is a common symptom of opioid withdrawal and can occur if clients continue to use opioids while taking the opioid antagonist naltrexone.

Case Study 15.4.3 §15.4 source ↗

Read the following clinical scenario to answer the questions that follow. This case study is a follow-up to Case Study Part A.

Six months after the last encounter, Daniel Nguyen, a 34-year-old client, presents to the primary care provider and reports that he has been doing well after starting therapy with buprenorphine-naloxone and reports no other opioid use. He states that withdrawal symptoms are minimal and manageable. He states that he now wishes for help with his cigarette-smoking habit.

History
Opioid use disorder: being treated with buprenorphine-naloxone
Cigarette smoking: smokes one pack per day for 7 years
Major depressive disorder

Current Medications
Buprenorphine-naloxone: 16 mg/4 mg orally daily
Duloxetine: 40 mg orally daily

Based on the information above, the nurse anticipates that the prescriber will most likely choose which medication for the client?
  1. a.
    Bupropion
  2. b.
    Lorazepam
  3. c.
    Naltrexone
  4. d.
    Methadone
Table 15.8 in the book ↗
Vital Signs Physical Examination
Temperature: 98.4°F

• Head, eyes, ears, nose, throat (HEENT): Within normal limits

• Cardiovascular: No jugular vein distention; no peripheral edema noted bilaterally; S1, S2 noted, rhythm regular

• Respiratory: Clear to auscultation bilaterally

• GI: Abdomen soft, nontender, nondistended

• GU: Reports adequate urine output

• Neurological: Alert and oriented to person, place, and time; no motor deficits noted

• Integumentary: No wounds noted; skin color appropriate for age

Blood pressure: 123/78 mm Hg
Heart rate: 74 beats/min
Respiratory rate: 16 breaths/min
Oxygen saturation: 99% on room air
Height: 5'8"
Weight: 175 lb

Answer

A. Bupropion
This is the only medication of the four listed that is indicated for smoking cessation.

Case Study 15.4.4 §15.4 source ↗

Read the following clinical scenario to answer the questions that follow. This case study is a follow-up to Case Study Part A.

Six months after the last encounter, Daniel Nguyen, a 34-year-old client, presents to the primary care provider and reports that he has been doing well after starting therapy with buprenorphine-naloxone and reports no other opioid use. He states that withdrawal symptoms are minimal and manageable. He states that he now wishes for help with his cigarette-smoking habit.

History
Opioid use disorder: being treated with buprenorphine-naloxone
Cigarette smoking: smokes one pack per day for 7 years
Major depressive disorder

Current Medications
Buprenorphine-naloxone: 16 mg/4 mg orally daily
Duloxetine: 40 mg orally daily

The provider prescribes varenicline for the client. When should the client discontinue use of tobacco-containing products?
  1. a.
    Immediately
  2. b.
    1 week after starting varenicline
  3. c.
    2 weeks before starting varenicline
  4. d.
    The same time as starting varenicline
Table 15.8 in the book ↗
Vital Signs Physical Examination
Temperature: 98.4°F

• Head, eyes, ears, nose, throat (HEENT): Within normal limits

• Cardiovascular: No jugular vein distention; no peripheral edema noted bilaterally; S1, S2 noted, rhythm regular

• Respiratory: Clear to auscultation bilaterally

• GI: Abdomen soft, nontender, nondistended

• GU: Reports adequate urine output

• Neurological: Alert and oriented to person, place, and time; no motor deficits noted

• Integumentary: No wounds noted; skin color appropriate for age

Blood pressure: 123/78 mm Hg
Heart rate: 74 beats/min
Respiratory rate: 16 breaths/min
Oxygen saturation: 99% on room air
Height: 5'8"
Weight: 175 lb

Answer

B. 1 week after starting varenicline
The client’s quit date should be one week after starting varenicline, to reduce withdrawal symptoms and increase chances for successful cessation.

15-1 §15.RQ source ↗

A nurse is evaluating a client in the emergency department, who states that they take oxycodone chronically for cancer-related pain but forgot their medication at home while on vacation. The client is experiencing severe pain, diarrhea, piloerection, sweating, and malaise. Which of the following phenomena should the nurse tell the client they are experiencing?
  1. a.
    Substance abuse
  2. b.
    Tolerance
  3. c.
    Withdrawal
  4. d.
    Psychological dependence

Answer

C. Withdrawal
This client had a sudden discontinuation of their oxycodone, leading to typical opioid withdrawal effects.

15-2 §15.RQ source ↗

A nurse is talking with a client at a primary care office, and the client states that they normally smoke a half pack of cigarettes per day but have recently stopped smoking abruptly. The client states they are physically fine, but they frequently find themselves thinking about smoking again and experiencing intense cravings to smoke another cigarette. Which of the following phenomena should the nurse tell the client they are experiencing?
  1. a.
    Intoxication
  2. b.
    Tolerance
  3. c.
    Physical dependence
  4. d.
    Psychological dependence

Answer

D. Psychological dependence
This client is experiencing the behavioral aspects of discontinuation of a substance, leading to intense cravings.

15-3 §15.RQ source ↗

What is the primary purpose of the Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) assessment instrument?
  1. a.
    Estimate the client’s alcohol consumption
  2. b.
    Manage withdrawal symptoms
  3. c.
    Assess for system disorders related to alcohol intake
  4. d.
    Plan outpatient behavioral therapy

Answer

B. Manage withdrawal symptoms
The Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) uses a symptoms-based approach to manage the symptoms of alcohol withdrawal as they occur.

15-4 §15.RQ source ↗

A client is brought to the emergency department via emergency services after being found in their car unresponsive to any stimuli. The nurse evaluating the client notices that they have slow, shallow breathing, are unresponsive to painful stimuli, and have pinpoint pupils. Which medication does the nurse anticipate the provider will prescribe for this client?
  1. a.
    Naloxone
  2. b.
    Chlordiazepoxide
  3. c.
    Methadone
  4. d.
    Disulfiram

Answer

A. Naloxone
This client is experiencing the triad of opioid overdose symptoms (respiratory depression, CNS depression, and miosis). This client requires quick reversal of these effects, so naloxone should be administered.

15-5 §15.RQ source ↗

A nurse is evaluating a client for treatment of their opioid use disorder. They have a history of intravenous use of agents such as oxycodone and heroin. Which medication is the prescriber most likely to order to deter intravenous abuse of the medication?
  1. a.
    Methadone
  2. b.
    Lorazepam
  3. c.
    Buprenorphine-naloxone
  4. d.
    Chlordiazepoxide

Answer

C. Buprenorphine-naloxone
The naloxone in this drug makes it so that if it is injected instead of being used orally, it will prevent the buprenorphine from causing as much euphoria as it would by itself.

15-6 §15.RQ source ↗

A nurse is educating a client with an opioid use disorder and their parent about how to recognize the signs and symptoms of opioid overdose and when to administer naloxone. Which of the following statements should the nurse make?
  1. a.
    “After giving naloxone, call emergency services immediately.”
  2. b.
    “Naloxone will last 2–3 hours.”
  3. c.
    “Naloxone has no adverse effects.”
  4. d.
    “Naloxone may induce seizures.”

Answer

A. “After giving naloxone, call emergency services immediately.”
Because of the short-acting nature of naloxone, it is imperative to call emergency services after naloxone administration to get definitive care prior to the client re-sedating.

15-7 §15.RQ source ↗

A nurse is collaborating with a client with a known alcohol use disorder who has recently been prescribed disulfiram. Which clinical effect should the nurse educate the client about if they decide to consume alcohol?
  1. a.
    CNS depression
  2. b.
    Flushing
  3. c.
    Withdrawal
  4. d.
    Seizures

Answer

B. Flushing
Facial flushing is one of the most characteristic reactions seen in clients consuming alcohol while using disulfiram.

15-8 §15.RQ source ↗

A client is being admitted to the hospital for pancreatitis, and the nurse managing the client learns that the client has a previously undisclosed alcohol use disorder and has been without any alcohol for the past 2 days. Which of the following withdrawal effects would the nurse expect this client to develop?
  1. a.
    Respiratory depression
  2. b.
    CNS depression
  3. c.
    Facial flushing
  4. d.
    Seizures

Answer

D. Seizures
Seizures are one of the most severe and potentially life-threatening effects that can be seen with alcohol withdrawal.

15-9 §15.RQ source ↗

A client is starting nicotine replacement therapy (NRT) for their nicotine use disorder. The nurse educating the client about the medication should make which of the following points?
  1. a.
    “If a child consumes any type of NRT, it should not cause any problems.”
  2. b.
    “NRT can make you sleepy, so no driving a car while using it.”
  3. c.
    “You should stop the NRT if you begin using tobacco again.”
  4. d.
    “NRT therapy will prevent tobacco products from working as well if you relapse.”

Answer

C. “You should stop the NRT if you begin using tobacco again.”
This is an important counseling point to avoid having the client receive excessive doses of nicotine, leading to toxicity.

15-10 §15.RQ source ↗

A client is being evaluated for therapy for their nicotine use disorder. The nurse notes in their history that the client has been diagnosed with a major depressive disorder but is not currently receiving any treatment for that condition. Which of the medications used for smoking cessation would the nurse anticipate the prescribing provider will initiate to both treat the client’s depression and help with smoking cessation?
  1. a.
    Bupropion
  2. b.
    Varenicline
  3. c.
    Naltrexone
  4. d.
    Chlordiazepoxide

Answer

A. Bupropion
Because bupropion is primarily used as an antidepressant and can reduce cravings during smoking cessation, it is an ideal medication to treat both conditions.

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Problems and answers are adapted from Pharmacology for Nurses by Tina Barbour-Taylor, Leah Mueller (Sabato), Donna Paris and Dorie Weaver, OpenStax, and are used under the CC BY-NC-SA 4.0 licence. Access for free at https://openstax.org/books/pharmacology/pages/1-introduction. Illustrations: Copyright Rice University, OpenStax, under CC BY-NC-SA 4.0 license. This adaptation is released under the same licence, is non-commercial, and is neither affiliated with nor endorsed by OpenStax or Rice University.